Blar i forfatter "Flygel, Trym Thune"

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    • Composition of gut microbiota of children and adolescents with perinatal HIV infection taking antiretroviral therapy in Zimbabwe 

      Flygel, Trym Thune; Sovershaeva, Evgeniya; Classen-Weitz, Shantelle; Hjerde, Erik; Mwaikono, Kilaza S.; Odland, Jon Øyvind; Ferrand, Rashida A.; McHugh, Grace; Gutteberg, Tore Jarl; Nicol, Mark P.; Cavanagh, Jorunn Pauline; Flægstad, Trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-24)
      <p><i>Background - </i>Human immunodeficiency virus (HIV) infection causes impairment of the gastrointestinal barrier, with substantial depletion of CD4<sup>+</sup> T cells in the gut. Antiretroviral therapy (ART) restores CD4<sup>+</sup> counts and may have beneficial effects on gut microbiota in adults. Little is known about effect of long-term ART on gut microbiome in HIV-infected children. We ...

    • Exhaled nitric oxide is associated with inflammatory biomarkers and risk of acute respiratory exacerbations in children with HIV-associated chronic lung disease 

      Flygel, Trym Thune; Hameiri-Bowen, Dan; Simms, Victoria; Rowland-Jones, Sarah; Ferrand, Rashida Abbas; Bandason, Tsitsi; Yindom, Louis-Marie; Odland, Jon Øyvind; Cavanagh, Jorunn Pauline; Flægstad, Trond; Sovershaeva, Evgeniya (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-07)
      Objectives: Chronic lung disease is a recognized complication in children with HIV. Acute respiratory exacerbations (ARE) are common among this group and cause significant morbidity. Exhaled nitric oxide (eNO) is a known marker of local airway inflammation. We investigated the association between eNO and ARE, biomarkers of systemic inflammation, and the effect of azithromycin on eNO levels.<p> ...

    • HIV Infected African Children: Gut microbiota in relation to chronic lung disease and long-term antibiotic treatment 

      Flygel, Trym Thune (Doctoral thesis; Doktorgradsavhandling, 2024-04-19)
      More than half of the population with HIV in the world live in sub-Saharan Africa. HIV-associated chronic lung disease is the most prevalent comorbidity among children and adolescents with HIV in this region. The pathogenesis is multifactorial and thought to be a result of chronic immune activation and repeated lung injury. CD4+ T-cells are the main target for HIV infection. As the majority of CD4+ ...

    • The role of tuberculosis coinfection on lung function of HIV infected children and adolescents in Africa. A systematic review 

      Flygel, Trym Thune (Master thesis; Mastergradsoppgave, 2019-06-01)
      Objectives: To systematically review existing literature on what role history of tuberculosis (TB) plays in lung function abnormalities and the development of chronic lung disease of HIV infected children and adolescents in Africa, as the burden of paediatric HIV and TB coinfection is the highest in this region. Methods: Systematic searches were performed in PubMed and EMBASE databases using PICO ...